Melanotan-1 vs Melanotan-2: Key Differences & Regulatory Status
Melanotan-1 and Melanotan-2 are both alpha-MSH analogues studied in the melanocortin pathway, but they differ in receptor selectivity and, importantly, in regulatory status.
7 min read · Published 2026-06-23
Melanotan-1 vs Melanotan-2: At a Glance
Both Melanotan-1 and Melanotan-2 are synthetic alpha-MSH analogues studied within the melanocortin system. The key differences are receptor selectivity and regulatory status — the latter being especially important.
Research use only. Both compounds are supplied for in-vitro laboratory research. Neither is a medicine, and neither is for human or veterinary consumption, administration, or therapeutic use.
How They Differ — Receptor Selectivity
Melanotan-1 is more selective for the melanocortin-1 receptor (MC1R). Melanotan-2 is a broader agonist acting across several melanocortin receptors (including MC1R, MC3R and MC4R). This breadth of activity is one reason the two are studied and regulated differently.
The Critical Difference — Regulatory Status
The closely related molecule to Melanotan-1, afamelanotide (Scenesse), is an approved medicine in the EU and US for a rare photosensitivity disorder under specialist supervision. Melanotan-2 is not approved by any regulator, and UK and other authorities have warned against unlicensed Melanotan-2 products sold for human use. Research-grade material of either is supplied for laboratory use only and is not for human or cosmetic use.
Sourcing for Research
See our individual guides for full detail on each, and our overview of UK peptide legality. View Melanotan-1 and Melanotan-2 product details.
Frequently Asked Questions
What is the difference between Melanotan-1 and Melanotan-2?
Melanotan-1 is more MC1R-selective and has an approved medical form (afamelanotide/Scenesse) for a rare condition; Melanotan-2 is a broader melanocortin agonist with no approval and regulatory warnings against human use.
Is either Melanotan approved in the UK?
Afamelanotide (related to Melanotan-1) is approved for a rare condition under specialist supervision; research-grade Melanotan-1 and all Melanotan-2 are unlicensed and supplied for laboratory use only.
Can either be used for tanning?
No. Research-grade Melanotan-1 and Melanotan-2 are supplied for laboratory use only and are not for human or cosmetic use.
Related Guides
- What Is Melanotan-1? Melanocortin Peptide Research Guide
- What Is Melanotan-2? Melanocortin Peptide Research Guide
- Are Research Peptides Legal in the UK? (2026 Complete Guide)
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