What Is CJC-1295 (No DAC)?
CJC-1295 without DAC is a 29-amino-acid analogue of growth hormone-releasing hormone, more precisely described as Modified GRF (1-29). It is a truncated GHRH fragment carrying four amino acid substitutions that slow enzymatic degradation relative to native GHRH.
The “No DAC” qualifier is the whole point of the compound and is routinely misunderstood. DAC — Drug Affinity Complex — is a maleimide group that binds serum albumin and extends the half-life to roughly a week. Without it, the half-life is on the order of thirty minutes. These are two materially different research tools sharing a name.
How It Is Studied to Work
As a GHRH analogue, CJC-1295 (No DAC) is studied for its action at the GHRH receptor on somatotroph cells of the anterior pituitary, where GHRH binding stimulates growth hormone synthesis and release.
Its short half-life is the reason it appears in pulsatile-release research: a brief signal more closely resembles endogenous GHRH secretion than a sustained one. It is frequently studied alongside a ghrelin-receptor agonist such as ipamorelin, because the two act through separate receptors and the combination is used to examine whether their effects are additive. See our CJC-1295 vs Ipamorelin comparison.
Evidence and Regulatory Status
CJC-1295 holds no marketing authorisation from the MHRA, the EMA or the FDA. The DAC-modified version was investigated clinically and development was discontinued; the no-DAC form has not completed clinical development for any indication. It is not a licensed medicine and is not approved for human or veterinary use.
It is also a prohibited substance in sport under the WADA Prohibited List, which is worth knowing if research involves samples from athletes.
Research Handling and Quality
Supplied lyophilised, it should be stored below −20°C for long-term stability and refrigerated once reconstituted. Reconstitute with bacteriostatic water down the vial wall, swirl rather than shake, and avoid repeated freeze-thaw cycles.
Because the no-DAC and DAC forms are visually identical as powders, identity verification matters more here than purity alone. Ask for the analytical method and the chromatogram rather than a summary percentage.
Frequently Asked Questions
What is the difference between CJC-1295 with and without DAC?
Is CJC-1295 (No DAC) the same as Mod GRF 1-29?
Why is it studied with Ipamorelin?
Is CJC-1295 approved for human use?
Related Guides
Products discussed in this guide are for research and laboratory use only. AllMyPeptides does not condone or support misuse of any research materials. Not for human or animal consumption.