Written by the AllMyPeptides Research Team
What Is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids. It is a partial sequence of the body protection compound originally isolated from human gastric juice. The amino acid sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.
BPC-157 has been studied for its potential effects on tissue repair, angiogenesis (formation of new blood vessels), and cellular protection. Research has explored its interactions with the nitric oxide (NO) system, growth factor expression, and collagen metabolism.
Important: BPC-157 is sold for research purposes only. It is not approved for human consumption, medical use, or as a food supplement in the UK or any other jurisdiction.
Molecular Properties
BPC-157 has a molecular formula of C62H98N16O22 and a molecular weight of 1419.5355 g/mol. It is typically supplied as a lyophilised powder that requires reconstitution with bacteriostatic water before use in research protocols. The peptide is stable at room temperature in its lyophilised form but should be stored at -20°C for long-term preservation.
Synthesis and Purity
BPC-157 is produced using solid-phase peptide synthesis (SPPS). At AllMyPeptides, every batch is tested by independent HPLC to verify 99%+ purity. A batch-matched Certificate of Analysis (COA) is included with every order, showing the HPLC chromatogram and mass spectrometry data.
Research Context and Applications
BPC-157 has been studied in various research contexts:
- Tendon and ligament research: Studies have examined effects on tendon fibroblasts, collagen production, and extracellular matrix remodelling.
- Angiogenesis research: Research has explored BPC-157 effects on VEGF expression and blood vessel formation in various tissue models.
- Gastrointestinal research: Given its origins from gastric juice, BPC-157 has been studied in models of GI mucosal integrity and gut barrier function.
- Muscle and connective tissue: Research has investigated its role in muscle regeneration and connective tissue repair mechanisms.
All research has been conducted in cell cultures and animal models only. No human clinical trials have been completed, and BPC-157 is not approved for any therapeutic use.
Storage and Handling
Proper storage is essential for maintaining BPC-157 integrity:
- Lyophilised: Store at -20°C for up to 2 years. Short-term storage at 2-8°C is acceptable for up to 6 months.
- Reconstituted: Store at 2-8°C and use within 30 days. Do not freeze.
- Light protection: Keep vials away from direct light. Amber vials or foil wrapping is recommended.
- Reconstitution: Use bacteriostatic water. Typical concentrations range from 2-5mg/ml depending on research requirements.
References
BPC-157 is supplied strictly for in-vitro laboratory research use only. The peer-reviewed references below are provided for research context and do not imply that the compound is safe or effective for use in humans.
- Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing. J Appl Physiol. 2011;110(3):774-780. View source
- Seiwerth S, et al. BPC 157 and standard angiogenic growth factors. Curr Pharm Des. 2018;24(18):1972-1989. View source
- Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide BPC 157 and musculoskeletal soft-tissue healing. Cell Tissue Res. 2019;377(2):153-159. View source
- Sikiric P, et al. Brain-gut axis and pentadecapeptide BPC 157. Curr Neuropharmacol. 2016;14(8):857-865. View source
Frequently Asked Questions
What is BPC-157 used for in research?+
Is BPC-157 legal in the UK?+
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