Written by the AllMyPeptides Research Team
What Is TB-500?
TB-500 is a synthetic peptide representing the 17-47 amino acid sequence (43 amino acids) of thymosin beta-4 (Tβ4), a naturally occurring protein found in virtually all mammalian cells. Thymosin beta-4 was first isolated from the thymus gland in the 1960s and has since been identified as a key regulator of actin polymerisation and cell migration.
TB-500 contains the active core of thymosin beta-4 that has been studied for its role in cell motility, tissue remodelling, and wound healing processes. The peptide has a molecular weight of approximately 4963.44 g/mol.
Molecular Characteristics
TB-500 is an acetylated peptide that promotes cell migration by regulating actin dynamics. Actin is a critical component of the cellular cytoskeleton, and its polymerisation state controls cell shape, adhesion, and movement. TB-500 has been studied for its binding interactions with actin monomers and its effects on filament formation.
Relationship to Thymosin Beta-4
While thymosin beta-4 is a 43-amino-acid protein containing 44 residues, TB-500 represents the biologically active fragment (residues 17-47) that retains the actin-binding and cell-migration properties. This fragment was identified through structure-activity relationship studies that mapped the functional domains of the full protein.
Research Applications
TB-500 has been investigated in several research areas:
- Cell migration studies: Research has examined TB-500 effects on keratinocyte and endothelial cell migration in wound healing models.
- Actin cytoskeleton research: Studies have explored the peptide role in regulating actin polymerisation and its downstream effects on cell morphology.
- Cardiac tissue research: Animal models have been used to study TB-500 effects on myocardial remodelling and cardiac tissue repair processes.
- Connective tissue research: Investigations into effects on tendon, ligament, and muscle tissue repair mechanisms.
All research has been conducted in in vitro cell cultures and animal models. TB-500 is not approved for human use.
Sourcing TB-500 in the UK
When purchasing TB-500 for research, verify the following:
- HPLC purity of 99%+ — demand a COA
- Independent third-party testing — not just in-house results
- Lyophilised powder form — more stable than pre-mixed solutions
- Proper packaging — vacuum-sealed, protected from light and heat
- UK-based supplier — faster shipping, easier returns, UK consumer protection
AllMyPeptides supplies TB-500 with independent HPLC verification, batch-matched COAs, and next-day UK delivery.
References
TB-500 (thymosin beta-4) is supplied strictly for in-vitro laboratory research use only. The peer-reviewed references below are provided for research context and do not imply that the compound is safe or effective for use in humans.
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin beta-4: a multi-functional regenerative peptide. Expert Opin Biol Ther. 2012;12(1):37-51. View source
- Crockford D, et al. Thymosin beta-4: structure, function and biological properties. Ann N Y Acad Sci. 2010;1194:179-189. View source
Frequently Asked Questions
What is the difference between TB-500 and thymosin beta-4?+
Is TB-500 legal to buy in the UK?+
What is the typical research dosage for TB-500?+
How should TB-500 be stored?+
Related Guides
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