Written by the AllMyPeptides Research Team
What Is CJC-1295?
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH), specifically modified from the first 29 amino acids of endogenous GHRH. The version commonly used in research includes Drug Affinity Complex (DAC) — a modification that extends its half-life by binding to albumin in the bloodstream.
CJC-1295 works through a different mechanism than GHSR agonists like Ipamorelin. While Ipamorelin binds to the GHSR-1a receptor, CJC-1295 binds to the GHRH receptor (GHRHR) on somatotroph cells in the anterior pituitary. This activates the Gs/cAMP signalling pathway, leading to increased GH synthesis and release.
AllMyPeptides supplies CJC-1295 (No DAC) + Ipamorelin in 10mg lyophilised vials, HPLC-tested to 99%+ purity with a batch-matched COA.
The DAC Modification
The Drug Affinity Complex (DAC) is a chemical modification added to CJC-1295 that allows it to bind reversibly to serum albumin. This binding extends the peptide circulating half-life from minutes to days in research models. The DAC modification consists of a reactive maleimide group that covalently attaches to free thiol groups on albumin, creating a slow-release reservoir in the bloodstream.
GHRH Receptor Mechanism
CJC-1295 binds to the growth hormone-releasing hormone receptor (GHRHR) on pituitary somatotrophs. This activates the Gs protein, which stimulates adenylyl cyclase to produce cAMP. Elevated cAMP activates protein kinase A (PKA), which triggers GH gene transcription and hormone release. This is the same pathway used by endogenous GHRH, making CJC-1295 a useful tool for studying this specific signalling cascade.
CJC-1295 in Combination Research
In research, CJC-1295 is often studied alongside Ipamorelin because they target different receptors in the GH axis:
| Feature | CJC-1295 | Ipamorelin |
|---|---|---|
| Receptor | GHRHR | GHSR-1a |
| Mechanism | GHRH analogue | Ghrelin mimetic |
| Pathway | Gs/cAMP/PKA | Gq/PLC/Ca²⁺ |
| Has DAC | Yes | No |
This complementary mechanism makes the combination valuable for research exploring the complete GH axis signalling network.
Storage and Sourcing
Storage requirements for CJC-1295:
- Lyophilised: Store at -20°C for up to 2 years. Protect from light and moisture.
- Reconstituted: Store at 2-8°C, use within 30 days. Do not freeze.
- Light sensitive: The DAC modification can degrade with prolonged UV exposure.
When purchasing CJC-1295, verify that the product includes DAC (if required for your research) and confirm 99%+ HPLC purity with an independent COA.
References
CJC-1295 is supplied strictly for in-vitro laboratory research use only. The peer-reviewed references below are provided for research context and do not imply that the compound is safe or effective for use in humans.
- Teichman SL, et al. Prolonged stimulation of GH and IGF-I secretion by CJC-1295 in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. View source
Frequently Asked Questions
What does DAC mean in CJC-1295?+
What is the difference between CJC-1295 and modified GRF?+
Is CJC-1295 legal in the UK?+
How should CJC-1295 be stored?+
Related Guides
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