Written by the AllMyPeptides Research Team
What Is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (5 amino acids) that acts as a selective growth hormone secretagogue. It was developed as a research tool for studying the growth hormone (GH) axis and has been investigated for its binding affinity to the growth hormone secretagogue receptor (GHSR-1a).
Ipamorelin belongs to the growth hormone-releasing peptide (GHRP) class. Unlike earlier non-selective secretagogues, ipamorelin was designed to be more selective for the GHSR-1a receptor, which has made it valuable for isolating GH pathway studies.
The peptide sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂ and it has a molecular weight of approximately 711.85 g/mol.
Selectivity Profile
Ipamorelin selectivity for GHSR-1a is one of its defining characteristics in research. Studies have compared its binding profile to other secretagogues and found it to have high affinity for GHSR-1a with minimal cross-reactivity to other related receptor subtypes. This selectivity makes it valuable for research focused specifically on the GHSR-1a pathway without confounding effects from other receptor interactions.
Molecular Properties
Ipamorelin is an artificial peptide containing one non-natural amino acid: D-2-naphthylalanine (D-2-Nal). It also contains an N-terminal amino acid substitution with Aib (α-aminoisobutyric acid), which provides increased resistance to enzymatic degradation. The C-terminus is amidated, which improves stability and receptor binding.
Research Applications
Ipamorelin has been studied in several research contexts:
- GHSR-1a receptor studies: Research exploring the structure-function relationship of the growth hormone secretagogue receptor and its signalling pathways.
- GH axis research: Studies investigating the mechanics of growth hormone release and the downstream effects on IGF-1 production.
- Comparative studies: Research comparing ipamorelin selectivity profile to other secretagogues to better understand receptor subtype differences.
- Metabolic research: Investigations into how GHSR-1a activation affects metabolic pathways in cell and animal models.
Storage and Sourcing
Proper storage is critical for maintaining ipamorelin integrity:
- Lyophilised: Store at -20°C for up to 2 years. Protect from light and moisture.
- Reconstituted: Store at 2-8°C, use within 30 days. Do not freeze.
- Concentration: Typically reconstituted at 1-2mg/ml depending on research protocol requirements.
When sourcing ipamorelin, verify 99%+ HPLC purity and request a batch-matched COA from an independent laboratory.
References
Ipamorelin is supplied strictly for in-vitro laboratory research use only. The peer-reviewed references below are provided for research context and do not imply that the compound is safe or effective for use in humans.
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. View source
Frequently Asked Questions
What receptor does ipamorelin bind to?+
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Is ipamorelin legal in the UK?+
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